Immunodeficiency and antiphospholipid immunoglobulin for exacerbations of chronic obstructive pulmonary disease and bronchial asthma
Agapova Y.R., Gulin A.V., Malysheva E.V.
Lipetsk State Technical University
The content of serum gamma-globulin fraction (by electrophoresis on cellulose acetate) and antiphospholipid antibodies (by indirect enzyme linked immunosorbent assay - ELISA) in patients with acute exacerbation of COPD and bronchial asthma was studied. A reduction in percentages of gamma-fraction below normal was found in 35.7%, 60.7% and 75.0% of patients with COPD II, III, and IV, respectively, and 22.2% of patients with asthma (p <0, 01). The extent of deficits was 10.9%, 16.2, 20.0% and 34.8% in patients with COPD I, II, III, and IV, respectively (p <0.001) and 25.2% for heavy and prolonged / or frequent exacerbations of asthma. Excess antibodies to phospholipids found in 16.4% of patients with COPD and in 29.6% of patients with asthma (p <0.001). Autoantibodies in 2 times more frequent in patients with low gamma-globulins long experience disease with moderate to severe disease severity. It was recommended that the identification and correction of such shifts.