English
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International journal of Immunopathology, allergology, infectology.

Complex diagnosis of different variants of fungal allergy at bronchial asthma

Titova N.D.

Clinically and laboratory examined 80 patients with bronchial asthma at the age of 18 to 60 years and 20 people without allergic diseases. Determined IgE, IgG, IgA antibodies, sensitization of granulocytes (in the reaction of release of myeloperoxidase) to fungal allergens - Penicillum, Alternaria tenuis, Candida albicans, Aspergilla fumigates, Rhizopus nigricans. Prick-test was positive in 17.5% of patients, IgE is present in the blood serum of 40,0%, IgG-antibodies - in 42,5%, IgA-antibodies - in 50,0%, sensitization of granulocytes was at 52.5 %. Sensitization to fungal allergens in laboratory data is quite high and reaches 75% in the population. In 14 out of 30 (46,7%) patients response to fungal allergens has been with the participation of IgE-antibodies (IgE-dependent variant) and 16 (53,3%) showed IgE-independent (non-IgE-antibodies in serum) variant of allergic reactions to fungal allergens. People with asthma need to use complex methods to eliminate sensitization to fungal allergens.

Keywords

Bronchial asthma, fungal allergens, prick-test, IgE-, IgG-, IgA-antibodies, sensitization of granulocytes.

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Reference

Titova N.D. Immunopathology, allergology, infectology 2011; 3:101-108