Clinical efficacy of intradermal autoserum therapy in patients with pollen allergy
Semenova I.V., Vykhrystenka L.R., Novikov D.K.
Vitebsk State Medical University, department of Clinical Immunology and Allergology
Background. Aim of this study was to evaluate the influence of preseason intradermal autoserum therapy (ACT) for the symptoms of allergic rhinitis, conjunctivitis, bronchial asthma (BA) caused by pollen allergens.
Materials and Methods. The analysis of the clinical symptoms of hay fever in 56 patients for two seasonspollinosis. In the first group (n = 34) patients received a course of autoserum therapy preseason and pollinosis season, if necessary, added standard pharmacotherapy (FT). Patients of the second group (n = 22) received only the FT during the exacerbation of pollinosis. The dynamics rinokonyunktival manifestations of pollinosis (T5SS), asthma symptoms (ACT-test), take into account the effectiveness of treatment by the physician and the patient.
Results. Preseason AST reduced rinokonyunktival manifestations of pollinosis (p <0.001) and pollen asthma symptoms (p = 0.02). In combination with pharmacotherapy (FT) was more effective than a pharmacotherapy, as by the physician and the patient’s opinion (p <0.01), and reduced need for drugs (p < 0.001).
Conclusion. Preseason autoserum therapy in combination with ongoing in acute pharmacotherapy is more effective in preventing relapses and treatment of pollinosis than monotherapy drugs.