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International journal of Immunopathology, allergology, infectology.

The role of peripheral blood gd T cells in idiopathic IgA-nephropathy development and progression

Yurkevich M.Y., Nizheharodova D.B., Zafranskaya M.M.

Belarusian Medical Academy of Post-graduate Education, Minsk, Belarus

The description of proliferative activity, phenotypic and secretory features of circulating gd T cells in idiopathic IgA-nephropathy patients was presented in this study. The research describes the role of this cell population in IgA-nephropathy development, which consists in the high level of CCR7 expression on gd T lymphocytes, cell migration to secondary lymphoid organ, CD40L (CD154)-mediated gd T- and B cells cooperation and the induction of humoral immune response. The prognostic significance of the low number of circulating gd T cells for the detection of IgA-nephropathy unfavorable course was shown.

Keywords

IgA-nephropathy, gd -cells, phenotype, pathogenesis, prognosis.

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Reference

Yurkevich M.Y., Nizheharodova D.B., Zafranskaya M.M. Immunopathology, allergology, infectology 2014; 1:71-79