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International journal of Immunopathology, allergology, infectology.

Metabolic activity of major and minor subsets of lymphocytes in children with atopic dermatitis

Balabolkin I.I., Petrichuk S.V., Kapustina E.Y., Izmailova T.D., Samokhina I.V., Kurbatova O.V., Miroshkina L.V., Dukhova Z.N., Semenova G.F.

FSBI ôScientific Centre of Children Healthö under the Russian Academy of Medical Sciences, Moscow, Russia

The article explores the state of energy metabolism in the major and minor subsets of lymphocytes in children with atopic dermatitis. We examined 62 children aged from 4 months to 16 years with atopic dermatitis. It was revealed lymphocytes mitochondrial dysfunction, characterized by the decreased activity of succinate dehydrogenase (SDH) with decreased SDH/NADH-D index in all children with atopic dermatitis. It was shown increase in number of following T-cells subsets: T-helpers (CD3+CD4+), Th17-lymphocytes (CD3+CD4+CD161+), regulatory T-lymphocytes (CD3+CD4+CD25+CD127) and activated T- helpers (CD3+CD4+CD25+CD127+) in the peripheral blood with decrease SDH activity. It was detected SDH decrease in B-cells (both B1 and B2-cells), Th2-lymphocytes and NK-cells. It was shown high clinical significance of pimecrolimus 1% external treatment in children with atopic dermatitis according to the lymphocytes metabolic activity dynamics.

Keywords

Atopic dermatitis, mitochondrial dehydrogenasis, succinate dehydrogenase, lymphocytes subsets, regulatory T-lymphocytes, pimecrolimus 1%.

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Reference

Balabolkin I.I., Petrichuk S.V., Kapustina E.Y., Izmailova T.D., Samokhina I.V., Kurbatova O.V., Miroshkina L.V., Dukhova Z.N., Semenova G.F. Immunopathology, allergology, infectology 2014; 2:24-33