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International journal of Immunopathology, allergology, infectology.

Clinical and immunological efficacy of allergen-specific immunotherapy and autoserogistaminotherapy at pollinoses and pollen asthma

Siamionava I.V., Vykhrystenka L.R., Novikau D.K., Yanchnk U.V., Smirnova A.U.

Vitebsk State Medical University

Studied the clinical and immunological efficacy of subcutaneous allergen-specific immunotherapy (ASIT) and autoserogistaminotherapy (ASGT) in 85 patients with pollen allergy. A reduction manifestations of rhinoconjunctivitis (p <0,001) and asthma symptoms (p <0,001) for both methods of treatment. ASIT and immunological effects were comparable ASGT: the increase in the levels of INF-γ (p <0,001), IL-10 (p <0.01) and TGF-β1 (p <0,01), decreased levels of IL-4 (p <0,05). After using ASGT recorded a decline in serum IgE (p <0,01), which may indicate a desensitizing effect of this treatment. After ASIT revealed a moderate correlation between increased levels of IL-10 and decrease of rhinoconjunctivitis symptoms the overall total score on a scale T5SS (r = 0,57) (p <0,05). In patients sensitized to pollen allergens only after ASIT, as well as increased levels of ASGT after INF-γ (p <0,05), IL-10 (p <0,05), TGF-β1 (p <0, 05), decreased levels of IL-4 (p <0,05). Patients with polyvalent sensitization to pollen and household allergens higher immunological efficacy obtained during ASGT: after therapy increased levels of INF-γ (p <0,05), TGF-β1 (p <0,01). It was established that in patients with sensitization to pollen allergens only the most efficient implementation of the courses ASIT combined with pharmacotherapy. When treating patients with polyvalent sensitization to pollen and household allergens should be preferred ASGT, combining it with pharmacotherapy.

Keywords

Hay fever, autoserogistaminotherapy, allergen-specific immunotherapy, cytokines, sensitization.

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Reference

Siamionava I.V., Vykhrystenka L.R., Novikau D.K., Yanchnk U.V., Smirnova A.U. Immunopathology, allergology, infectology 2014; 3:29-38