Interrelation of changes of levels matriksny metalproteinases - 8 and - 9 with the allergy to dentoprosthetic materials
Vitebsk State Medical University
Results of comparative immunofermental research of the contents the matriksnykh metalproteinases (MMP)-8 and-9 in oral liquid of people with various constructional materials of restorations of teeth and tooth alignments are presented.
The system of a proteoliz including family the matriksnykh of metalproteinases is characterized by increase in activity of MMP-8 and-9 in a saliva of patients with intolerance of dentoprosthetic materials respectively 33,3 mg/ml and 37,3 mg/ml (in control group – 9 mg/ml and 14 mg/ml).
It is revealed that MMP-8 and-9 can serve in oral liquid as a marker of an allergy to dentoprosthetic materials on what specifies the correlation analysis of the obtained data between results of RAPL and the MMP-8 and MMP-9 levels of vyyavshiya the following dependences: 1) direct strong correlation of RAPL (ZnCl2 0,01%) and MMP-8 levels (R=0,76; p=0,001) and MMP-9 (R=0,8; p=0,001); 2) direct moderate correlation of RAPL (CrCl3 0,01%) and MMP-8 levels (R=0,49; p=0,0019) and MMP-9 (R=0,34; p=0,04); 3) direct moderate correlation of RAPL (NiCl2 0,01%) and MMP-8 levels (R=0,52; p=0,001) and MMP-9 (R=0,57; p=0,001); 4) direct moderate correlation of RAPL (CoCl2 0,005%) and MMP-8 levels (R=0,53; p=0,005) and MMP-9 (R=0,36; p=0,02).
Executed researches it is actual for further development of express methods of identification of patients with high risk of developing of an allergy to dentoprosthetic materials.