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International journal of Immunopathology, allergology, infectology.

Interrelation of changes of levels matriksny metalproteinases - 8 and - 9 with the allergy to dentoprosthetic materials

Karpuk I.Yu.

Vitebsk State Medical University

Results of comparative immunofermental research of the contents the matriksnykh metalproteinases (MMP)-8 and-9 in oral liquid of people with various constructional materials of restorations of teeth and tooth alignments are presented.
The system of a proteoliz including family the matriksnykh of metalproteinases is characterized by increase in activity of MMP-8 and-9 in a saliva of patients with intolerance of dentoprosthetic materials respectively 33,3 mg/ml and 37,3 mg/ml (in control group 9 mg/ml and 14 mg/ml).
It is revealed that MMP-8 and-9 can serve in oral liquid as a marker of an allergy to dentoprosthetic materials on what specifies the correlation analysis of the obtained data between results of RAPL and the MMP-8 and MMP-9 levels of vyyavshiya the following dependences: 1) direct strong correlation of RAPL (ZnCl2 0,01%) and MMP-8 levels (R=0,76; p=0,001) and MMP-9 (R=0,8; p=0,001); 2) direct moderate correlation of RAPL (CrCl3 0,01%) and MMP-8 levels (R=0,49; p=0,0019) and MMP-9 (R=0,34; p=0,04); 3) direct moderate correlation of RAPL (NiCl2 0,01%) and MMP-8 levels (R=0,52; p=0,001) and MMP-9 (R=0,57; p=0,001); 4) direct moderate correlation of RAPL (CoCl2 0,005%) and MMP-8 levels (R=0,53; p=0,005) and MMP-9 (R=0,36; p=0,02).
Executed researches it is actual for further development of express methods of identification of patients with high risk of developing of an allergy to dentoprosthetic materials.

Keywords

Oral liquid, allergy, matriks metalproteinases

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Reference

Karpuk I.Yu. Immunopathology, allergology, infectology 2014; 3:57-69