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International journal of Immunopathology, allergology, infectology.

Recurrence, reinfection and longterm efficacy of antifungals in onychomycosis by 2013

Sergeev A.Y., Mokina E.V., Savchenko N.V., Sergeev V.Yu., Burtseva G.N.

The practice and future developments in topical and systemic treatments for onychomycosis often meet with problems of evaluating endpoint clinical and mycological cure, establishing longterm efficacy, the rates of recurrence and reinfection. This may add to the discrepancy between the data of modern clinical trials resulting in significant variation of efficacy data (20 to 60 per cent). The metaanalyses of major international trials in longterm efficacy offer some clues to the causes of treatment failure and possible efficient solutions. We have conducted a 4year study on longterm efficacy of modern regimens of antifungal treatment in onychomycosis. Reinforced with new data on comparative efficacy of topical antifungals, such as allylamines including 1% naftifine, various imidazole formulations and other compounds, we may be confident now with possibility of effective treatment and prevention of the reinfection in onychomycosis. The Russian developments of the recent years include new technologies and recommendations on evaluation of clinical and mycological cure rates, individual and communal prevention guidelines.


Onychomycosis, relapse, reinfection, antifungals, diagnosis, treatment, prevention, metaanalysis, clinical trials

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Sergeev A.Y., Mokina E.V., Savchenko N.V., Sergeev V.Yu., Burtseva G.N. Immunopathology, allergology, infectology 2013; 3:90-99