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International journal of Immunopathology, allergology, infectology.

Effect of cryoprecipitate on the parameters of the immune status of patients with cirrhosis of the liver

Karpova R.V., Chernousov A.F., Horobryh T.V.

Studied the cellular link immune system (CD3 +, CD4 +, CD8 +, CD4 / CD8, CD19 +, CD16 + CD56 +, CD3 + HLADR +) in 16 patients suffering from cirrhosis of the liver before and after stimulation of regeneration of liver tissue cryoprecipitate. The control group consisted of 10 patients, a cellular link, they were examined before and one year after conservative therapy. According to the results of our study, in patients with cirrhosis of viral etiology, Class A, B and C by ChildPugh, marked activation of cellular and humoral immune system in 3 months after the administration of cryoprecipitate in the liver. In patients without virus infection after 3 months was revealed activation of T cellmediated immune system, due to suppression of helper and cytotoxic lymphocyte population. Subpopulation of lymphocytes (HLADR +), which indicates the activation of the immune process, according to our data, decreased after 3 months stimulate the regeneration of cirrhotic liver, in both study groups. A year later, after the introduction of cryoprecipitate in the liver, the activity of cellular and humoral immunity persisted in 2 study groups, by reducing the cytotoxic lymphocyte population. Comparing these results with the clinical  laboratory data, we observed a normalization of blood biochemical parameters, the absence of jaundice, decreased viral load (PCR). A year later, all 10 patients in the control group, marked immunodeficiency, due to an increase of cytotoxic lymphocyte subpopulations, increased late activation marker (HLADR +) and decrease humoral immunity. Thus, cryoprecipitate entered intrahepatically patients with cirrhosis of the liver, Class A, B, C on the Child Pugh, activates cellular and humoral immunity during the year, reducing the activity of liver disease. Reduced cell mediated immune system in patients with decompensated cirrhosis of the class C ChildPugh, is an unfavorable factor leading to death.

Keywords

Cryoprecipitate, cirrhosis of the liver, cellular part of the immune system

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Reference

Karpova R.V., Chernousov A.F., Horobryh T.V. Immunopathology, allergology, infectology 2013; 2:6-12