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International journal of Immunopathology, allergology, infectology.

On the problem of pharmacological intolerance in antituberculosis therapy

Gurova Ya.V., Mordyk A.V., Puzyreva L.V.

Omsk State Medical Academy, Omsk

The purpose of the review is consideration of a problem of the low efficiency of treatment of tuberculosis connected with many factors one of which is the intolerance of antitubercular preparations. Data on specific features of the genes defining a metabolism of xenobiotics are submitted, the genetic factors connected with features of their farmakodinamika are allocated. The priority of studying of a role of fermentativny system of a metabolism in biotransformation of medicines is shown. Studying of polymorphism of genes of this system in various populations which are shown distinctions in efficiency of medicamentous therapy is perspective in practical application.
Despite the wide arsenal of chemotherapeutic means for treatment of tuberculosis existing today the phthisiatrician often faces a problem of development of the optimum scheme of treatment of the specific patient. Studying of a genotype of patients will allow to develop fenotipichesky approach in treatment of such patients. The role of genetic markers of predisposition to tuberculosis is shown in the review. The role of polymorphism of genes of a detoxication as predictors of the response to medicinal therapy is presented.
Continuation of studying of the genes which are taking part in a detoxication of antitubercular preparations represents scientific and practical interest. The obtained data will allow to put the personified approaches to carrying out chemotherapy at patients with tuberculosis and to increase of its efficiency.

Keywords

Polymorphism of genes, genome, CYP, R450, tuberculosis, antitubercular preparations

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Reference

Gurova Ya.V., Mordyk A.V., Puzyreva L.V. Immunopathology, allergology, infectology 2015; 1:52-58