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International journal of Immunopathology, allergology, infectology.

Interrelations between tuberculin adherent mononuclears and antiştuberculin antibody levels in course of pulmonary tuberculosis

Seregina V., Budritsky A.

Vitebsk State Medical University, Vitebsk, Republic of Belarus

In patients diagnosed with pulmonary tuberculosis for the first time that show positive clinico-radiological and laboratory dynamics after two months of intensive treatment, a moderate direct correlation was discovered between the number of tuberculin adherent monocytes, tuberculin adherent monocytes with higher expression of CD 14 receptors, and anti-tuberculin antibodies. In patients with negative clinico-radiological and laboratory dynamics during treatment, a strong inverse correlation between the number of severe tuberculin adherent monocytes, tuberculin adherent monocytes with higher expression of CD 14 receptors after 2 months of treatment, and antituberculin antibodies in one month. During complex treatment in combination with meglumine acridonacetate, the correlation between the number of tuberculin adherent monocytes, tuberculin adherent monocytes with higher expression of CD 14 receptors, and antituberculin antibodies increases. A strong correlation between the number of tuberculin adherent monocytes and tuberculin adherent monocytes with higher expression of CD 14 receptors was discovered throughout the entire intensive treatment phase.

Keywords

Tuberculosis, treatment, tuberculin adherent monocytes, antituberculin antibodies, correlation

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Reference

Seregina V., Budritsky A. Immunopathology, allergology, infectology 2015; 1:59-63