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International journal of Immunopathology, allergology, infectology.

Dynamics of humoral immune factors in the plasma of women at different stages of ontogenesis

Frolova L., Frolov A., Fushtej I., Prilutsky A., Koltsova I.

Zaporozhye Medical Academy of Postgraduate Education

The humoral immune factors were studied in blood plasma of 116 women of varying ages. In healthy women of reproductive age antiendotelial antibodies (AEAT) to plasmolemma structures were not revealed. C-reactive protein and proinflammatory cytokines (IL-8, IL-1, TNF-alpha) were at the base tested level. A significant number of perimenopausal and postmenopausal women has high levels of AEAT and pro-inflammatory factors, which were higher in essential hypertension (EH). Thus high levels of the tested humoral immunological factors in the blood plasma of women in menopause must be controlled, and in the case of constantly increasing therapy must be ordinated.


Perimenopause, postmenopause, autoantibodies, cytokines, hypertension.

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Frolova L., Frolov A., Fushtej I., Prilutsky A., Koltsova I. Immunopathology, allergology, infectology 2013; 2:20-24. DOI: 10.14427/jipai.2013.2.20