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International journal of Immunopathology, allergology, infectology.

An intrabuccal method of diagnosing allergy by increasing peroxidase activity in the saliva of

Novikov D.K., Novikov P.D., Karpuk I.Y., Lazarenko L.L., Smirnova A.U., Alyahnovich N.S.

1 Vitebsk State Medical University, Vitebsk, Belarus
2 NMC Molecular Medicine Spbgmu them. Acad. Pavlov, St. Petersburg, Russia

A method for diagnosing allergy to allergens (food, home dust, drugs and chemicals, dental materials, metal salts), as well as non-specific hypersensitivity (pseudoallergy) irritants and pollutants (cigarette smoke, car exhaust fumes, etc.) was described. For this the increase of peroxidase activity was determined in the saliva before and after challenging a patient with the test substance or allergen. The presence or absence of sensitization of leukocytes of the oral mucosa (i.e. allergy and hypersensitivity) was determined according to the color intensity of substrate-chromogen mixture.

Keywords

Allergy, hypersensitivity, diagnosis in vivo, saliva.

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Reference

Novikov D.K., Novikov P.D., Karpuk I.Y., Lazarenko L.L., Smirnova A.U., Alyahnovich N.S. Immunopathology, allergology, infectology 2015; 4:35-43