Decrease of the IgE-antibodies levels after intradermal autoserum therapy in children with atopic bronchial asthma
Minina E.S., Novikov P.D.
Vitebsk State Medical University, Vitebsk, the Republic of Belarus
Objective. To evaluate clinical and immunological effectiveness of intradermal autoserum therapy in children with atopic bronchial asthma (BA).
Materials and methods. Study group consisted of 51 children 5 to 6 years old with allergic bronchial asthma with sensitization to house dust mite allergens, all of whom had been prescribed a course of autoserum therapy with a basic medical treatment. In the control group (n=15) 5 to 14, autoserum therapy was not used. The quantitative analysis of serum IgE- and IgG-antibodies to the mite mixt D. pteronyssinus and D. farinae, interleukin 10, transforming growth factor-β1 (TGF-β1) was performed both before the treatment and afterwards.
Results. A statistically significant decrease in the level of IgG antibodies to the micro house dust mites (p=0,000001) in the group of children with autoserum therapy was registered. In the control group without autoserum therapy, the level of IgG-antibodies to the mite mixt D. pteronyssinus and D. farinae (p=0,0007) increased, whereas the level of TGF-β1 decreased (p=0,002). When comparing the two groups, higher levels of IgE-antibodies (p=0,011) and IgG-antibodies (p=0,00003) were seen in the group with medication without autoserum therapy after treatment. In evaluating the clinical efficacy of the treatment using the asthma control test, after-six-months control improvement was found in the group of children who had received a course of autoserum therapy (p<0,001).
Conclusion. Intradermal autoserum therapy causes a decrease in the level of IgG-antibodies to the indoor allergens D. pteronyssinus, D. farinae allergens, improves asthma control in children with bronchial asthma.