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International journal of Immunopathology, allergology, infectology.

Early diagnostics and mathematical prediction models remodeling of the heart at patients with atopic bronchial asthma

Soloveva I.A., Sobko E.A., Demko I.V., Kraposhina A.Yu., Gordeeva N.V., Eydemiller N.S., Burakov A.Yu.

1 Krasnoyarsk budgetary state medical university named after prof. V.F.Voino-Yasenetsky, ministerstv of public health service of the Russian Federation, Krasnoyarsk, Russian Federation
2 Regional Clinical Hospital, Krasnoyarsk, Russian Federation

Research objective. To create the mathematical model of forecasting the remodeling of heart at atopic bronchial asthma for optimization the diagnostics of heart and vascular complications.
Materials and methods: 188 people were examined: 148 patients were divided into groups taking into account severity of a disease: mild, middle and severe. Studying of vessels regulating function of an endothelium was carried out by an ultrasonic method on the device VividTM-S6 (Germany). The concentration of YNF-α, IL-6, IL-4, IL-5, IL-10, INF-γ and osteopantini in a blood plasma defined by ELISA. The linear mathematical models are developed for forecasting of change of the diastolic dysfunction of a myocardium.
Results: The chronic persistent inflammation at asthma contributes to the disruption of the cardiovascular system. The value of osteopontin increases in the presence of diastolic dysfunction of the heart. It was established that the severity of the progression of bronchial asthma with development of considerable violations in the bronchial tree and more expressed by the damaging action of a gipoksemiya in combination with markers of an inflammation aggravate endotelialny damage and promote the development of diastolic function disorders both left and right ventricles.
Conclusions: Was shown the clinical value of determination of the level of osteopantiniin a peripheric blood for the purpose of early diagnostics of cardiovascular events that allows to consider this marker as the most perspective target for long laboratory monitoring of remodeling of heart at patients with bronchial asthma.

Keywords

Bronchial asthma, system inflammation, endotelialny dysfunction, remodeling of heart, diastolic dysfunction.

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Reference

Soloveva I.A., Sobko E.A., Demko I.V., Kraposhina A.Yu., Gordeeva N.V., Eydemiller N.S., Burakov A.Yu. Immunopathology, allergology, infectology 2015; 4:53-62