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International journal of Immunopathology, allergology, infectology.

Immuno-biochemical markers predict relapse of pyelonephritis

Korol L.V., Driyanskaya V.E., StepanovaáN.M., Migal L.A.

SI ôInstitute of Nephrology of NAMS of Ukraine", Kiev, Ukraine

The purpose of research - to evaluate the possibility of determining the transforming growth factor-β (TGF-β) and the oxidative stress index (OSI) as a prognostic biomarker recurrent course of pyelonephritis (PN).
Materials and methods.The content of TGF-β in the urine and OSI values in serum of blood were determined before treatment in 67 women with PN aged 18 to 59 years (mean 36 ▒ 7,7 years) and 30 healthy persons (control). Relapse within PN (more than 3 episodes in year) is ascertained in 48 women (group 1), 19 women had worsening of PN up to 2 times in year (group 2). The recurrence rate at the 1-st group - 6,0 ▒ 2,9, the 2nd group - 1,5 ▒ 0,5 times in year (p <0.001).
Results. It is shown that the value of TGF-β and the OSI at the first group patients (3,5 ▒ 1,5 pg / ml and 4,49 ▒ 0,18 standard units) is probably higher than those in patients of the control group (0,36 ▒ 0.02 pg / ml and 1,036 ▒ 0,04 standard units, p <0.001) and at the 2-nd group patients (1,2 ▒ 0,5 pg / ml and 2,31 ▒ 0,14 standard units, p <0.001). Also, the value of TGF-β and the OSI at the 2-nd group patients probably exceed the values ​​at the control group (p <0.001). Analysis of ROC curves indicates that the registration content of TGF-β > 2 pg / ml, and the OSI values> 2.5 standard units the probability of developing recurrent PN forecast 97.6% of cases.
Conclution. Thus, the determination of TGF-β and the OSI may be used as prognostic biomarkers recurrent course PN, allowing timely adequate therapy, increase its promises more effective and reduce the frequency of relapses.

Keywords

Transforming growth factor-β, oxidative stress index, prognostic biomarkers, recurrent pyelonephritis.

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Reference

Korol L.V., Driyanskaya V.E., StepanovaáN.M., Migal L.A. Immunopathology, allergology, infectology 2015; 4:93-97