𡽽ŕŔÚ English
Aims and scope Subscription Info for authors Editorial Board Contacts
International journal of Immunopathology, allergology, infectology.

Determination of androgen receptors in cells of triple negative breast cancer

Krylov A.Y., Krylov Y.V., Yanchanka U.V.

1 Institute of improvement of professional skill and retraining of personnel of the State committee of judicial examinations of Belarus, Minsk, Belarus
2 Vitebsk regional clinical pathoanatomical bureau, Vitebsk, Belarus
3 Vitebsk State Medical University, Vitebsk, Belarus
4 JSC ôScientific-research enterprise Resanö, Vitebsk, Belarus

The presence of androgen receptor (AR) in the cells of triple negative breast cancer was detected immunohistochemically. Androgen receptors were found in 11 (22%) from 50 cases of triple-negative breast cancer. The number of malignant cells with androgen receptor from the total breast cancer cells number was from 1 to 55%, the mean value ľ 25 ▒ 22%.
There were not metastases in regional lymph nodes in any case of the AR+ triple-negative breast cancer. AR+ cells of the triple negative breast cancer metastasize to regional lymph nodes significantly slower compared with AR-cells of the triple negative breast cancer. There were metastases to the regional lymph nodes in 5 cases (12.8%), distant metastases - in 1 case (2.6%) in patients with AR-triple negative breast cancer. The androgen receptors determination in breast cancer cells by immunohistochemistry is prognostically valuable.

Keywords

Androgen receptor, triple-negative breast cancer, monoclonal antibody, immunohistochemistry

Fulltext in PDF

Open file
Size: 854 KB

Reference

Krylov A.Y., Krylov Y.V., Yanchanka U.V. Immunopathology, allergology, infectology 2016; 1:32-36

DOI

10.14427/jipai.2016.1.32