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International journal of Immunopathology, allergology, infectology.

Features of hpv infection HIV-infected pregnant women

Baranovskaya E.I., Kustova M.A., Javoronok S.V.

Belorusian State Medical University, Minsk, Belarus
Gomel State Medical University, Gomel, Belarus

Research purpose to identify the immunological and virological features of co infection caused by HPV, and HIV in pregnant women.
Material and methods. The study included 113 pregnant women: 61 HIV-infected pregnant women (study group) and 52 HIV-negative pregnant women without cervical and external genitalia pathology (the comparison group). Used methods: cytological, histological, colposcopic, molecular genetics and statistical.
Results. Genital papillomatosis was diagnosed in 24.6% of HIV-infected pregnant women, including one woman combination of papillomatosis and CIN. HPV in the genital tract found in 64% of HIV-infected pregnant women and 40% in the control group, in both groups, 95% have a high carcinogenic risk HPV (WRC), the viral load (VL) of HPV have no different. The presence of HPV WRC in HIV-infected women is associated with a viral load of HIV, more than 500 copies/ml (p <0,001) and a low level of CD4-cells in the blood (p = 0.049). Ascending HV HIV in the blood up to 15770 copies/mL at term birth increases the risk of HPV infection (Se = 75,0; Sp = 93,3), HV HIV in the blood is directly related to HPV in the genital tract BH (rs = 0,89) and HPV BH directly correlates with the number of HPV genotypes (p = 0,01). The use of anti-retroviral drugs (ARV drugs) during pregnancy reduces the chances of HPV infection.
Conclusion. HPV-associated pathology in HIV-positive pregnant women with HIV depends on BH, BH HPV, carcinogenic risk HPV genotypes, the use of antiretroviral drugs.

Keywords

Human papilloma virus, HIV, pregnancy.

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Reference

Baranovskaya E.I., Kustova M.A., Javoronok S.V. Immunopathology, allergology, infectology 2016; 1:50-56

DOI

10.14427/jipai.2016.1.50