Features of human papillomavirus infection in HIV-infected pregnant women
Baranovskaya E.I., Kustova M.A., Javoronok S.V.
Belorusian State Medical University, Minsk, Belarus
Gomel State Medical University, Gomel, Belarus
Research purpose – to identify the immunological and virological features of co infection caused by HPV, and HIV in pregnant women.
Material and methods. The study included 113 pregnant women: 61 HIV-infected pregnant women (study group) and 52 HIV-negative pregnant women without cervical and external genitalia pathology (the comparison group). Used methods: cytological, histological, colposcopic, molecular genetics and statistical.
Results. Genital papillomatosis was diagnosed in 24.6% of HIV-infected pregnant women, including one woman combination of papillomatosis and CIN. HPV in the genital tract found in 64% of HIV-infected pregnant women and 40% in the control group, in both groups, 95% have a high carcinogenic risk HPV (WRC), the viral load (VL) of HPV have no different. The presence of HPV WRC in HIV-infected women is associated with a viral load of HIV, more than 500 copies/ml (p <0,001) and a low level of CD4-cells in the blood (p = 0.049). Ascending HV HIV in the blood up to 15770 copies/mL at term birth increases the risk of HPV infection (Se = 75,0; Sp = 93,3), HV HIV in the blood is directly related to HPV in the genital tract BH (rs = 0,89) and HPV BH directly correlates with the number of HPV genotypes (p = 0,01). The use of anti-retroviral drugs (ARV drugs) during pregnancy reduces the chances of HPV infection.
Conclusion. HPV-associated pathology in HIV-positive pregnant women with HIV depends on BH, BH HPV, carcinogenic risk HPV genotypes, the use of antiretroviral drugs.