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International journal of Immunopathology, allergology, infectology.

Study of allergenic and locally irritant action of preparation “Eferol, spray”

Romanova M.A., Dairov A.K., Seidakhmetova R.B., Shnaukshta V.S., Adekenov S.M.

1 Joint-stock company “International research and production holding “Phytochemistry”, Karaganda, Republic of Kazakhstan
2 Test Center "National center of examination of medicines, medical devices and medical equipment", Almaty, Kazakhstan

The aim of this study was a research of the allergenic and locally irritating effect of the drug "Eferol spray".
Methods. Possible allergenic and locally irritating effect was studied using the method of skin application, on the model of "general anaphylaxis reaction (anaphylactic shock)", on the model of "conjunctival sample", as well as using indirect test degranulation of mast cells.
Results. It was noted the presence of study drug "Eferol, spray” certain allergenic potential, identified in the study of allergenic effect on the model of "general anaphylaxis reaction". It was found the ability of the researched drug to induce delayed hypersensitivity reaction with repeated enteral introduction. The drug "Eferol spray" does not have skin sensibility activity in the study by cutaneous applications and conjunctival samples.

Keywords

Preclinical studies, allergenic action, “Eferol, spray”, locally irritant action

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Reference

Romanova M.A., Dairov A.K., Seidakhmetova R.B., Shnaukshta V.S., Adekenov S.M. Immunopathology, allergology, infectology 2016; 2:61-66

DOI

10.14427/jipai.2016.2.61