Immunopathogenetic changes at the women infected of the human papilloma virus
Vitebsk state medical university, Vitebsk
Objective: study of immunological parameters in women infected with different types of HPV and the development of a comprehensive approach to the treatment of women with
cervical disease caused by HPV infection.
Materials and methods: The study involved 47 women with HPV infection and 20 healthy women. To evaluate the intensity of the cellular immune response to antigens (L1) HPV 6, 11, 16, 18 types of immunological tests performed: the reaction of blast transformation of lymphocytes (RBTL) on HPV antigens, RBTL HPV antigens, mixed culture blast interleukin-2 (IL-2) cells, determination immunophenotype lymphocytes CD3+,
CD4+, CD8+, CD25+, CD22+, reaction lymphocyte sensitization to antigens, by definition they enhance the expression of the receptor for interleukin-2 under the influence of HPV antigens 6, 11, 16, 18 types, determination of serum immunoglobulins G, M, A.
Main results: In article the analysis immunological changes at women of reproductive age at various clinical variants papillomavirus infection. Are formulated prognosis criteria defining a current of pathological process. Ways of increase of efficiency of treatment HPV of an infection are planned.
Conclusion: HPV infection is determined by the decrease in CD2+, CD3+, CD4+ lymphocyte receptors, reducing immunoregulatory index CD4+ / CD8+. Defective helper T cell immunity in patients with HPV infection explains the long duration of infection and susceptibility to activation with the development of subclinical and clinical manifestations. High expression of IL2R-α (CD25+) and increase in the proliferation of T-lymphocyte blast cells in the cultures to AG HPV after addition of interleukin-2 in patients with HPV infection, indicating insufficient production of endogenous IL-2. Normalization of cellular immunity system and eliminate the deficit of endogenous production of IL-2 will facilitate an adequate immune response and, in the end, – the elimination of HPV.