Neuromimunnal mechanisms of development of pain syndrome
Moseikin I.A., Levashova A.I., Myagkova M.A.
1 Institute of Physiologically Active Substances of the Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
2 Russian Medical Academy of Postgraduate Education, Moscow
The purpose of this review is to generalize and analyze the results of studies of the mechanism of the development of pain syndromes, to evaluate the role of molecular receptors common for nervous and immunocompetent cells, in the combined regulation of pain control systems and immune responses. The opiate nociception system refers to the basic structures of pain signal suppression. It includes opioids, usually short peptides, which are ligands of interaction with mu, kappa and delta receptors. Endogenous opioids provide a biochemical link between the brain, neuroendocrine and immune system. Anti-opiate system, carries out homeostatic control of antinociceptive opiate effects. The questions of possible mechanisms of regulation of pain sensitivity and immunocompetence of the organism are considered.