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International journal of Immunopathology, allergology, infectology.

Immunomodulators and antioxidants in correction of immune and oxidatic disturbances at the chronic ischemia of the brain

Shulginova A.A., Bystrova H.A., Karaulov A.B.

1 FSBI of the HE źKursk state medical university╗ of the Russian Ministry of Health, Kursk, Russia
2 FSBI of the HE źFirst Moscow state medical university of name I.M. Sechenova╗ of the Russian Ministry of Health, Moscow, Russia

Objective: To establish the efficacy and Mexicor Glutoxim correction of immune and oxidant disturbances in chronic brain ischemia stage I and II.
Methods: The clinical study, the definition of immune and oxidative status in the blood plasma and erythrocytes.
Results: Before treatment of stage I and II disease found an increase in the level of pro- and anti-inflammatory cytokines, increased activity of neutrophils oxygen-systems, the development of oxidative stress. After a course of drug therapy that included antihypertensive drugs, metabolic, nootropic and antioxidant activity (Mexicor), set the normalization of 30.4% and the correction in the direction of healthy donors were 56.5% in laboratory parameters with the I and respectively 36.0% and 44.0% with stage II disease.
Conclusions: The effectiveness of the inclusion of Glutoxim was higher.

Keywords

Chronic cerebral ischemia stage I and II, immune and oxidative disturbances, Mexicor, Glutoxim.

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Reference

Shulginova A.A., Bystrova H.A., Karaulov A.B. Immunopathology, allergology, infectology 2017; 1:25-30

DOI

10.14427/jipai.2017.1.25