Immunomodulators and antioxidants in correction of immune and oxidatic disturbances at the chronic ischemia of the brain
Shulginova A.A., Bystrova H.A., Karaulov A.B.
1 FSBI of the HE źKursk state medical university╗ of the Russian Ministry of Health, Kursk, Russia
2 FSBI of the HE źFirst Moscow state medical university of name I.M. Sechenova╗ of the Russian Ministry of Health, Moscow, Russia
Objective: To establish the efficacy and Mexicor Glutoxim correction of immune and oxidant disturbances in chronic brain ischemia stage I and II.
Methods: The clinical study, the definition of immune and oxidative status in the blood plasma and erythrocytes.
Results: Before treatment of stage I and II disease found an increase in the level of pro- and anti-inflammatory cytokines, increased activity of neutrophils oxygen-systems, the development of oxidative stress. After a course of drug therapy that included antihypertensive drugs, metabolic, nootropic and antioxidant activity (Mexicor), set the normalization of 30.4% and the correction in the direction of healthy donors were 56.5% in laboratory parameters with the I and respectively 36.0% and 44.0% with stage II disease.
Conclusions: The effectiveness of the inclusion of Glutoxim was higher.