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International journal of Immunopathology, allergology, infectology.

Congenital HIV-infection in Obstetrics

Teslova O.A.

Educational establishment źGomel State Medical University╗

The article is dedicated to the problem of pregnancy in perinatally HIV-infected women. Meta-analysis of 13 publications was performed and it was discovered, that in perinatally HIV-infected women sexually transmitted infections were diagnosed in 52.4% cases, pregnancies were complicated in 77.6%. The rate of preeclampsia was significantly higher(11.1%, ­ = 0,006) as well as the rate of olighydramnious (12.5%, ­ = 0,039) and fetal growth retardation (13.7%, ­ = 0.097), the rate of miscarriage was significantly lower (5,8%, ­ = 0,006). The high rate of antiretroviral prophylaxis in perinatally HIV-infected pregnant women (97.9%) and connected with this adequate viral suppression in labor (71.6%) decreases the risk of intranatal HIV-transmission in preterm and vaginal delivery, but suboptimal viral suppression is the most significant (­ = 0,067) predictor of the HIV-transmission from mother to a child.

Keywords

HIV, perinatally infected, pregnancy complications, antiretroviral prophylaxis, transmission.

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Reference

Teslova O.A. Immunopathology, allergology, infectology 2013; 2:77-83

DOI

10.14427/jipai.2013.2.77