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International journal of Immunopathology, allergology, infectology.

Congenital HIVinfection in Obstetrics

Teslova O.A.

The article is dedicated to the problem of pregnancy in perinatally HIVinfected women. Metaanalysis of 13 publications was performed and it was discovered, that in perinatally HIVinfected women sexually transmitted infections were diagnosed in 52.4% cases, pregnancies were complicated in 77,6%. The rate of preeclampsia was significantly higher (11,1%, =0,006) as well as the rate of olighydramnious (12,5%, =0,039) and fetal growth retardation (13,7%, =0,097), the rate of miscarriage was significantly lower (5,8%, =0,006). The high rate of antiretroviral prophylaxis in perinatally HIVinfected pregnant women (97,9%) and connected with this adequate viral suppression in labor (71,6%) decreases the risk of intranatal HIVtransmission in preterm and vaginal delivery, but suboptimal viral suppression is the most significant (=0,067) predictor of the HIVtransmission from mother to a child.

Keywords

HIV, perinatally infected, pregnancy complications, antiretroviral prophylaxis, transmission.

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Reference

Teslova O.A. Immunopathology, allergology, infectology 2013; 2:77-83