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International journal of Immunopathology, allergology, infectology.

Viral hepatitis C, first detected in pregnancy

Znovets T.V., Baranovskaya E.I., Zhavoronok S.V., Anisko L.A., Goshkevich E.A., Shiptenko I.L.

1 Belarusian State Medical University, Minsk, Republic of Belarus
2 City clinical hospital of infectious diseases, Minsk, Republic of Belarus
3 The 3rd Klumov clinical hospital, Minsk, Republic of Belarus

Objective: to identify factors that promote infection by hepatitis C virus (HCV) reproductive age women and the diagnosis of viral hepatitis in connection with reproductive function.
Material and methods. The study included 178 pregnant women, of whom 80 women hepatitis C (H) diagnosed during the current pregnancy (1 study group), 98 patients were aware of the disease until the present pregnancy (2 group comparison). Use the methods: immunoassay, molecular-genetic and statistical.
Results. This pregnancy is planned in 62.5% of women in group 1 and 53.1% group 2. Diseases, sexually transmitted infections, were found in a significantly greater number of women in group 2 (p = 0,034). There is a significant probability to identify HC during pregnancy in patients without surgery (p = 0.011) or with a history of trauma (p = 0.031). The mechanism of infection with HCV was not significantly set in 66.3% cases in group 1 and 46.9% in group 2, at the same time as the probable cause of infection with HC a significant proportion of women reported execution of beauty treatments at home or in the salon (p <0.0001). The antiviral hepatitis C therapy with a known diagnosis of pregnancy to receive only 6.1% of women. A significant proportion of patients with HC co-infected with HIV, with a high rate of newly diagnosed cases of HIV infection in pregnancy.
Conclusions. Diagnosis of HC in women of reproductive age are often due to the need of clinical and laboratory examination according to clinical protocols with dispensary observation of maternity leave. The medical examination should include testing patients for the diagnosis of HC markers during medical examinations, treatment in hospital, people at risk.

Keywords

Hepatitis C, pregnancy, reproductive age.

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Reference

Znovets T.V., Baranovskaya E.I., Zhavoronok S.V., Anisko L.A., Goshkevich E.A., Shiptenko I.L. Immunopathology, allergology, infectology 2017; 2:15-23

DOI

10.14427/jipai.2017.2.15