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International journal of Immunopathology, allergology, infectology.

Immunological pecularities of recipients of renal transplant

Zybleva S., Zyblev S., Novikov P., Svistunova E., Shitikova M.

1 SI źThe Republican Research Center for Radiation medicine and Human Ecology╗, Gomel, Belarus
2 EI źGomel State Medical University╗, Gomel, Belarus
3 EI źVitebsk State Medical University╗, Vitebsk, Belarus

Objective. To study immunopathological disorders in renal allograft recipients with terminal stage of chronic kidney disease.
Material and Methods. There were studied 119 medical cases of patients with terminal renal insufficiency (tCKD). The amount of leucocyte subpopulation CD19+, CD3+, CD3-CD16+CD56+, CD3+CD16+CD56+, CD3+CD4+, CD3+CD8+, and as well as of lymphocytes expressing activation receptors of CD3+HLA-DR+, CD3+CD38+, CD3+CD8+HLA-DR+, immunoglobulins G, A, Đ3- and Đ4-components of the complement were assessed within the patients.
Results. There was detected a decrease of the main subpopulations of T lymphocytes CD3+ lymphocytes (­abs=0,033), T helper CD3+CD4+ (­rel=0,002 and pabs=0,001) and T-cytotoxic lymphocytes CD3+CD8+ (­rel=0,006 and ­abs=0,001), CD3-CD16+CD56+ lymphocytes (­abs=0,045) within the patients with terminal stage of chronic kidney disease who were on renal replacement therapy; an increase of the subpopulation of TNK-lymphocytes (CD3+CD16+CD56+) (­rel=0,015) was also detected; an increase in the concentration of C4 component of the complement was detected (p=0,014). There was detected positive level correlation of C3-component of the complement (rs=+0,49; ­=0,007), C4-component of the complement (rs=+0,37; ­=0,049) and CIC (rs=+0,4; ­=0,029) with the duration of the hemodialysis, and C3-component of the complement (rs=+0,79; ­=0,034), CIC (rs=+0,39; ­=0,0334), IgG (rs=+0,845; ­=0,008) and IgA (rs=+0,732; ­=0,039) with the duration of peritoneal dialysis.
Conclusion. Thus, the immune system dysfunction within the patients with terminal kidney disease on renal replacement therapy in the form of hemodialysis or peritoneal dialysis is associated with a change in the quantitative composition, functional activity and cooperation between immunocompetent cells.

Keywords

chronic kidney disease, dialysis, immunodeficiency, lymphocyte subpopulation

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Reference

Zybleva S., Zyblev S., Novikov P., Svistunova E., Shitikova M. Immunopathology, allergology, infectology 2017; 2:51-57