The factors of intercellular cooperation in immunogenesis of pyelonephritis

Drannik G.N., Driyanska V.E., Gaysenyuk F.Z., Rudenko M.Yu., Stepanova N.M., Bagdasarova I.V., Savchenko V.S., Lavrenchuk O.V., Rudenko A.V., Kruglikov V.T.

The study showed the increase in the level of pro (IL1,17, 18, 23, TNF
, MCP1) and antiinflammatory cytokines (IL 4, TGF), secretory leucocyte protease inhibitor (SLPI), the number of cells expressing the intercellular adhesion molecule1 – ICAM1 (CD54+) in patients with pyelonephritis (PN), peculiarities in acute and chronic PN. The high SLPI level was stated in serum and urine, which can be used, like the cytokine production, as an additional diagnostic and prognostic markers during the process of treatment.