Etiological factors of recurrent inflammatory diseases of the oropharynx – the first step to understanding the problem
Shchubelko R.V.,Zuikova I.N., Shuljenko A.E.
Multidisciplinary Medical Center "Clinic K+31", Moscow
Institute of Immunology Federal Medical Biological Agency, Moscow, Russian Federation
The aim of the study was to determine the spectrum of the bacterial and viral composition of the oropharyngeal microflora in patients with frequent recurrences of inflammatory diseases of the upper respiratory tract (UPT) and to determine the
possible role of a persistent herpesvirus infection in maintaining chronic inflammation. On the basis of NRC Institute of Immunology FMBA of Russia, 204 patients with recurrent chronic inflammatory diseases of the oropharynx were examined on an outpatient basis. The patients were examined outside the period of exacerbation. It turned out that in often sick adult microbial landscape outside the period of exacerbation,consists of a combined bacterial-viral microflora. In this case, the bacterial flora is predominantly opportunistic (64.2%), and much less pathogenic
(35.8%), mainly Staphylococcus aureus (31%). Herpesviruses occur in 52-80% of cases in the study group, which is significantly higher than their detection in the comparison group. Herewith, the most significant representative of the herpes group is the Epstein-Barr virus (EBV), whose DNA is found in the oropharynx of often ill adults in 65%, whereas in the comparison group in 19% of cases. The concentration of detectable
herpesviruses in the study group is significantly higher than in the comparison group, where we see either the absence of viruses or a low viral load. Thus, the microbiological landscape of the oropharynx in frequently ill adults is represented by both bacterial and viral agents that affect the mechanisms of local immunity of the mucous membranes, which eventually leads to the depletion of their protective properties and immunological insolvency.