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International journal of Immunopathology, allergology, infectology.

The study of polymorphism of cytokine genes IL4, IL10, IL17A and TNFA in patients with infectious dependent bronchial asthma

Kostina E.M., Molotilov B.A., Levashova O.A., Osipova M.V.

In 111 patients with a diagnosis of infectiondependent bronchial asthma, a study of gene polymorphism of interlekin IL4 (C589T), IL10 (G1082A), IL17(G197A) and TNF (G308A) with the use of testsystems Ltd PTT Liteh (Moscow) by method of polimerase chain reaction (PCR) in the mode of real time was conducted. The most common genotype: CT IL4 (C589T) have 54,05%, GA IL10 (G 1082A) have 70,27% and GA IL17A (G197A) have 67,57% of patients. A mutated homozygote was allocated according to IL4 TT (C589T) only in 6 patients (5,41%), according to IL 10 AA (G1082A) in 3 (2,70%) and TNF AA (G308A) in 3(2,70%) patients. Polymorphism of gene determines the features of atopy and chronic infectious process. The genotypes of hetorozygotes and mutant homozygotes for all types of genes cytokines are predictor of severe astma, torpid to the antyinflammatory therapy.

Keywords

Bronhial asthma, pathogenesis, cytokines, genes, polymorphism

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Reference

Kostina E.M., Molotilov B.A., Levashova O.A., Osipova M.V. Immunopathology, allergology, infectology 2013; 1:53-58