Comparative analysis of IL-4, IL-10, IL-6, IL-8 cytokines in nonalergic bronchial asthma and chronic obstructive pulmonary disease
Trushina E.Yu., Kostina E.M., Baranova N.I., Molotilov B.A., Tipikin V.A.
The Penza Institute for Further Training of Physicians ľ Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education źRussian Medical Academy of Continuous Professional Education╗ of the Ministry of Healthcare of the Russian Federation, Penza
163 people participated in the study. The study purpose was comparative analysis of spontaneous and induced production of IL-4, IL-10, IL-6, IL-8 in serum of patients with non-allergic bronchial asthma form (NABA) and chronic obstructive pulmonary disease (COPD). The investigative material was the spontaneous and phytohemaglutenin-induced production supernatant of the patient`s cells.
In the basis of neutrophilic inflammation in patients with NABA and COPD, both spontaneous and induced production of IL-6 and IL-8 cytokines play a leading role (p<0.05). IL-8 values were higher in COPD, whereas IL-6 production dominated in NABA (p<0.05). IL-4 and IL-10 levels were higher in NABA patients (p<0.05). Studied cytokines play an important role in the pathogenesis of both asthma and COPD.