English
Aims and scope Subscription Info for authors Editorial Board Contacts
International journal of Immunopathology, allergology, infectology.

The importance of helminthic microRNAs in pathology

Pobyarjin V.V., Pashinskaya E.S., Semenov V.M.

Vitebsk State Medical University, Vitebsk, Belarus

Helminthiasis is one of the most common diseases of humans and animals. Universal mechanism that parasites use to create optimal living conditions in the host organism, is the change in the expression of its genes with the participation of microRNAs, which are multitargeted. On the one hand, miRNA can participate in the regulation of a large number of protein-coding genes, and on the other the structural gene is a target for many microRNAs. Parasites have microRNAs similar to those synthesized in the human body. The impact of parasites on the processes of molecular synthesis through positive and negative regulation of microRNAs can lead to disruption of cell proliferation and differentiation, followed by the launch of blastomogenic mechanisms, the development of neurological disorders, as well as serve as an aggravating factor in the progression of infectious diseases. Further evaluation of post-transcriptional microRNAs will reveal the mechanisms of parasite-host relationship management.

Keywords

Helminths, microRNAs, mechanisms, cancer.

Fulltext in PDF

Open file
Size: 176 KB

Reference

Pobyarjin V.V., Pashinskaya E.S., Semenov V.M. Immunopathology, allergology, infectology 2019; 2:25-31

DOI

10.14427/jipai.2019.2.25