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International journal of Immunopathology, allergology, infectology.

Eosinophil extracellular traps: mechanisms of formation, functions

Minina E.S., Novikov P.D.

Vitebsk State Order of Peoples Friendship Medical University, Vitebsk, Republic of Belarus

This article presents current data about a new mechanism of antimicrobial action of eosinophilic granulocytes the formation of eosinophil extracellular traps (EETs). In this article, conditions and basic stages of EETs formation, the difference between apoptosis and necrosis of eosinophils are given. The distinctive features of EETs are described in comparison with neutrophil extracellular traps. Main structural components, as well as the factors that stimulate EETs appearance, are characterized. The mechanisms of antimicrobial activity of EETs are described.

Keywords

Eosinophils, granular proteins, eosinophil extracellular traps, immune system, DNA.

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Reference

Minina E.S., Novikov P.D. Immunopathology, allergology, infectology 2019; 2:38-48

DOI

10.14427/jipai.2019.2.38