Laboratory monitoring of the post-vaccinal humoral immunity to the measles virus

Ereshchenko A.A. , Gusyakova O.A., Gilmiyarova F.N., Sonis A.G., Nenyaykin S.S.

Samara State Medical University, Samara
Clinics of Samara State Medical University, Samara

The aim of the study was dynamic laboratory monitoring of the content of post-vaccination IgG to measles virus. Basic and dynamic determination of specific antibodies was carried out by the ELISA («Vector-Best»). 1166 previously vaccinated adults were examined, 34,39% of individuals did not have specific humoral immunity. Then a group of seronegative individuals was formed (n = 30), and vaccinated twice again. The average content IgG to measles virus 1 month after vaccination was 1,20±0,656 IU/ml; 1 month after revaccination – 1,14±0,573 IU/ml; after a year – 1,0±0,671 IU/ml. Identified interindividual differences in the formation and maintenance of a humoral immune response to measles vaccination are described. One person did not form specific immunity; and three persons did not survive it. Laboratory monitoring is an important component of efficiency assessment of vaccination.