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International journal of Immunopathology, allergology, infectology.

Variants of dysimmunoglobulinemia in children with frequent respiratory infections

Povorova O.V., Titova N.D., Livinskaya V.A., Vishnyakov M.N.

Mogilev State A. Kuleshov University, Republic of Belarus
Belarussian Medical Academy of Post Graduate Education
Belarusian-Russian University, Mogilev, Republic of Belarus
Mogilev regional medical and diagnostic center

In 60,2% (308 out of 512) of children aged 1-16 years of Mogilev region with repeated respiratory infections, the content of total serum immunoglobulins IgG, Ig, Ig is within the age limits. Correlations between the total serum immunoglobulins of children whose immunoglobulin values are outside the reference intervals and children whose immunoglobulin values are within the reference intervals have statistically significant differences. 39,8% of children aged 1-16 years have dysimmunoglobulinemia, and its frequency increases with the age of children: up to ten years within the average values for the entire group of children (1-2 years -26,4%, 3-5 years -27,6%, 6-9 years 31,5%), 10-13 years 50,5%, 14-16 years 75,8%. In children with immunoglobulin values that go beyond the values of reference intervals (RI), the following 13 variants of combining the levels of total serum immunoglobulins are most common: IgGRI-IgA↓, IgGRI-IgM↑, IgGRI-IgM↓, IgRI-IgG↑, IgRI-IgG↓, IgRI-IgM↑, IgRI-IgM↓, IgRI-IgG↑, IgRI-IgG↓, IgRI-IgA↓, IgA↓-IgG↓, IgA↑-IgG↑, IgM↓-IgG↓, IgM↓-IgA↓.

Keywords

Disimmunoglobulinemia, IgA, IgG, IgM, recurrent respiratory tract disorders, children

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Reference

Povorova O.V., Titova N.D., Livinskaya V.A., Vishnyakov M.N. Immunopathology, allergology, infectology 2020; 2:6-14

DOI

10.14427/jipai.2020.2.6