Acquisition and medical application of pooled mesenchimal stem cells
Rynda E.G., Antonevich N.G., Goncharov À.E.
The Institute of Biophysics and Cell Engineering of National Academy of Science of Belarus, Minsk, Belarus
Mesenchymal stem cells (MSCs) have established themselves as a cell product for the treatment of a wide range of diseases. However, there are limitations to the use of autologous MSCs associated with the impossibility of accumulating a sufficient amount of cellular biomass from a single donor, as well as the aberrant characteristics of cells obtained from sick people. Another problem is the extensive individual heterogeneity of properties and characteristics of MSCs of different donors. In recent years, more and more evidence has appeared that pooled cultures of allogeneic MSCs (poolMSC) have more pronounced and stable immunomodulating properties, compared with MSCs obtained from a single donor. Due to their proven immunomodulatory and regenerative potential, as well as safety and good tolerance, the use of poolMSC in medicine looks promising.
The purpose of this article was to study the currently available literature data that describe the morphological, functional and immunophenotypic properties of the pooled cultures of MSCs, as well as the experience of their application in preclinical studies.