Perifollicular cutaneous microbiota in acne patients. Part I.
Common patterns of colonization and resistance to systemic antimicrobials
Burceva G.N., Sergeev A.Yu., Arzumanyan V.G., Sergeev Yu.Yu.
Central Research Dermatology Clinic, Moscow
I.M. Sechenov First Moscow State Medical University
I.I. Mechnikov Institute of Vaccines and Sera, Moscow
Microbial colonization of human skin with permanent and transient microbiota may add to complexity of understanding the pathogenic mechanisms and treatment choices in several chronic cutaneous conditions, including acne. Propionibacteria, staphylococci and Malassezia spp. may induce or maintain the inflammatory processes in sebaceous glands and on skin surface. We have observed 873 acne adultorum patients to find substantial levels of skin colonization with staphylococci, S.aureus in particular. The colonization patterns display correlations with a number of clinical and epidemiological features of acne, and with profiles of antimicrobial resistance towards antibiotics and chemotherapeutic agents administered systemically. Most strains appeared to be resistant to tetracyclines, macrolides and co-trimoxazole, sensitive to cephalosporins, lincomycin and fluorochinolones. The results may provide new evidence for revising the established treatment approaches in antimicrobial administration in acne patients.