Indicators of cellular immunity and myeloid-derived suppressor cells of myeloid origin in children with psoriasis

Kuptsova D.G., Radygina T.V., Murashkin N.N., Petrichuk S.V.

Federal State Autonomous Institution "National Medical Research Center for Children's Health" of the Ministry of Health of the Russian Federation, Moscow

Federal State Budgetary Institution of Continuing Professional Education "Central State Medical Academy" Office of the President of the Russian Federation, Moscow

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow

Federal State-funded budgetary public health facility "Central Clinical Hospital of the Russian Academy of Sciences", Moscow

In this study, we presented a comprehensive assessment of major and small populations of lymphocytes, as well as the content of myeloid-derived suppressor cells (MDSCs) and their subpopulations in 132 children with psoriasis, for the first time. The results obtained by using flow cytometry and patient data analysis, showed that levels of MDSCs significantly increased in the blood of patients with psoriasis compared to healthy children. We found a direct correlation between Th17-lymphocytes and regulatory T-cells (Treg), activated by T-helper cells, MDSCs. We also found that the severity of the condition in children with psoriasis, estimated by the PASI, directly correlates with the content of Th17-lymphocytes and the M-MDSCs. In children with psoriasis methotrexate therapy decreases the number of T-lymphocytes and B-cells. However, the content of B-cells, T-helpers and Treg significantly increased in the treatment on BTPs compared with the group of children on external therapy.