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International journal of Immunopathology, allergology, infectology.

The state of cellular immunity in children with recurrent respiratory diseases

Povorova O.V.

Mogilev State A. Kuleshov University, Mogilev, Belarus

In children with recurrent respiratory diseases, deviations from the norm of various parameters of the immunity system were determined in more than 85% of cases. The most part of children with indicators outside the range of reference values of the subpopulations of lymphocytes is determined at the age of 3-6 years. In children, a decrease in B lymphocytes (CD19+), as well as T-cytotoxic lymphocytes (D3+D8+), is accompanied by an increase in T cells (CD3+) and T helper cells (CD3+CD4+). The most frequent variants of combined disorders of the parameters of the cellular link of immunity were determined: a decrease in B-lymphocytes and an increase in T-cells and T-helpers - in 40.2% (206 out of 512 children); a decrease in B-lymphocytes and a decrease in T-cytotoxic ones - in 42% (215 of 512). Similar correlations between cellular immunity indicators in frequently ill children of Mogilev and Minsk regions were determined: positive Spearman correlation coefficients between CD3/CD4 and CD3/CD8 T- cells, negative-between CD4/CD8 T- cells. The proportion of children with indices of T- and B-lymphocyte subpopulations within the normal range is higher in children of the Minsk region compared with children in the Mogilev region for all the studied subpopulations of lymphocytes (P<0.05). There were no differences in the leukocyte-T-lymphocyte index between the two groups of children.


T-lymphocytes, B-lymphocytes, T-helper, T-cytotoxic, children with recurrent respiratory diseases

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Povorova O.V. Immunopathology, allergology, infectology 2020; 4:64-74. DOI: 10.14427/jipai.2020.4.64