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International journal of Immunopathology, allergology, infectology.

Activity of hydrolytic enzymes of innate immunity in bacterial and coronaviral pneumonia

Zemko V.Y.,Okulich V.K, Lepteeva T.N., Zemko Y.Y., Frolova A.V.

Vitebsk State Medical University, Vitebsk, Belarus
Minsk City Clinical Oncological Dispensary, Minsk, Belarus

The aim of this work was to study the enzymatic activities of hydrolases in the blood serum of patients with bacterial pneumonia, pneumonia caused by SARS-CoV-2 and practically healthy volunteers who made up the comparison group. A number of blood serum enzymes related to innate immunity were determined: lysozyme, elastase, BAPNAamidase and deoxyribonuclease activity. Results: it was shown that blood serum in pneumonia caused by SARS-CoV-2 has the highest level of elastase and lysozyme activities, which significantly (p<0,001) exceeded the corresponding activities of sera amongst patients with bacterial pneumonia and in the comparison group. It was also found that trypsin-like activity of blood serum was increased in bacterial pneumonia in comparison with pneumonia caused by SARS-CoV-2 (p <0,001). There were no statistically significant differences in the level of deoxyribonuclease activity of blood serum among analyzed groups.

Keywords

Elastase, lysozyme, serine proteases, deoxyribonuclease activity of serum.

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Reference

Zemko V.Y.,Okulich V.K, Lepteeva T.N., Zemko Y.Y., Frolova A.V. Immunopathology, allergology, infectology 2021; 1:6-12

DOI

10.14427/jipai.2021.1.6