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International journal of Immunopathology, allergology, infectology.

Change of cellular and humoral immunity in the blood and the level of nitrates/nitrites, depending on the time since of death

Denisenko A.G., Danushenkova N.M.

To establish the remoteness of death changes of leukocytes the amount of T" and B"lymphocytes were analyzed in dynamics by the method of rosetting with erythrocytic CD3, CD4, CD8, CD25, CD22 diagnosticum sets, and NO concentration in plasma was determined, as well. Disturbances of changes in the amount of T" and B"lymphocytes expressing molecules" markers CD3, CD4, CD8, CD25, CD22. Dramatic elevation of NO concentration in plasma was observed in 2"6 hours time interval. Further the decrease of NO concentration was recorded in 7"16 hours time interval in case of deaths due to CHD and in the time interval 12"21 hours in case of deaths due to mechanical traumas. The detected changes of immune indices and NO concentration in plasma may be used to establish the remoteness of death in medicolegal practice.

Keywords

Time since of death, T" and B"lymphocytes, expression of molecules CD3, CD4, CD8, CD22, CD25, level of nitrates/ nitrites

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Reference

Denisenko A.G., Danushenkova N.M. Immunopathology, allergology, infectology 2012; 4:44-50