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International journal of Immunopathology, allergology, infectology.

Possibilities of quantiferon test in detection of latent tb infection

Surkova L.K., Strinovich A.L., Budnik O.A., Bahtina A.D.

Republican Scientific and Practical Center for Pulmonology and Phthisiology, Minsk, Belarus

Objective: to determine the capabilities of the quantiferon test in detecting latent tuberculosis infection in patients with comorbid pathology.
Materials and methods. A retrospective analysis of the quantiferon test results was carried out in 420 patients with suspected tuberculosis or with a hyperergic Mantoux or Diaskintest reaction using the QuantiFERON-TB Gold Plus test system (Qiagen, Germany).
Results. Different levels of tuberculosis infection were established in different age groups of patients with comorbid pathology, with a higher infection rate at a young age 21.42%. The shift of tuberculosis infection to an older age group (61-70 years) was determined 16.32%. Latent tuberculosis infection was significantly more often detected in patients with comorbid pathology compared to healthy individuals (59.0% and 32.78%, respectively, χ2=8.45, p=0.004).
Conclusion. The data obtained confirms the assumption of a high level of latent tuberculosis infection in patients with comorbid pathology.

Keywords

M. tuberculosis, latent tuberculosis infection, quantiferon test

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DOI

10.14427/jipai.2022.2.31

Reference

Surkova L.K., Strinovich A.L., Budnik O.A., Bahtina A.D. Immunopathology, allergology, infectology 2022; 2:31-34. DOI: 10.14427/jipai.2022.2.31