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International journal of Immunopathology, allergology, infectology.

Features of primary immunodeficiency during pregnancy: clinical case

Negodnova E.V., Iskandyarova M.S., Krasnoglazova K.A., Radaeva O.A.

National Research Ogarev Mordovia State University, Saransk

Primary immunodeficiencies (PIDs) are a group of hereditary diseases in which individual parts of the immune system do not function properly. Most often, patients first present with clinical symptoms in childhood, but some defects may not be recognized until later in life, such as common variable immune deficiency (CVID). The desire to have a child in people suffering from PID may be accompanied by a fear of complications in the mother and the birth of a child with immunodeficiency. Management of pregnancy in women with PID is recommended with the joint participation of an obstetrician-gynecologist and an allergist-immunologist. We report a favorable outcome in a patient with CVID who continued to receive intravenous immunoglobulin replacement therapy during pregnancy.


Pregnancy, primary immunodeficiency, common variable immune deficiency, immunoglobulins for intravenous administration

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Negodnova E.V., Iskandyarova M.S., Krasnoglazova K.A., Radaeva O.A. Immunopathology, allergology, infectology 2024; 1:57-62. DOI: 10.14427/jipai.2024.1.57