Genotypes of human papillomavirus in pregnant women
Baranouskaya A.I., Kustova M.A., Zhavoronok S.V., Teslova O.A., Suetnov O.N.
Aim. To investigate the presence of human papillomavirus and its genotypes in pregnant women with HPV-associated genital pathology and HIV infection.
Material and methods. We examined pregnant women of the Gomel region for the detection of HPV in the cervix epithelium. The study included 109 patients at one of the criteria: 1) the pathology associated with human papillomavirus infection – cervical intraepithelial neoplasia (CIN) and squamous epithelial abnormalities lesions of the cervix and / or genital warts (n = 65), 2) pregnant women with HIV infection (n = 44).
The presence of HPV DNA, viral genotype, viral load was determined with the PCR kits of reagents AmpliSens (Russia).
Results. We investigated the presence of HPV and its genotypes in pregnant women with HPV-associated genital pathology and HIV infection.
Conclusion: CIN and genital warts occur with equal frequency in pregnant women, genital warts are diagnosed more frequently in the HIV/ HPV co-infection (87,5 ± 12,5%; P = 0.02). HIV-negative pregnant women have significantly smaller number of genotypes, in comparison to HIV-positive, viral load is directly correlated with the number of genotypes (p = 0.035) and the presence of clinical manifestations of HPV (p = 0.007). HPV type 52 is more prevalent in HIV-positive pregnant women (P = 0.005).