Heterogeneity of inflammatory changes in prostate tissue in its benign hyperplasia

Ishchanka A.U., Badyoukov A.Y., Ogrizko V.S.

Vitebsk State Medical University, Vitebsk, Belarus

Introduction. Benign prostatic hyperplasia is an overgrowth of stromal and epithelial tissues in the transition and periurethral zones of the prostate gland in men over forty years of age, which leads to the appearance and progression of symptoms of urinary disorders. The etiology of this pathology has not yet been definitively identified. Among the factors of hyperplasia progression is chronic inflammation in the prostate tissue. However, the characteristics of this inflammation have not been sufficiently studied.
The aim of the study was to evaluate the morphological variants of inflammatory changes in BPH tissue, to find their possible correlation with changes in the laboratory data of the examined patients.
Materials and Methods. A retrospective study of a group of patients operated on for BPH at the first urological department of the Vitebsk Regional Clinical Hospital.
Results. The study revealed morphological signs of inflammation in the removed BPH tissue. Inflammatory infiltration differed statistically in the localization of inflammatory infiltrates, their prevalence, and the severity of the inflammatory process.
Conclusion. The study revealed phenotypic heterogeneity of morphological signs of inflammation in postoperative BPH tissue samples.