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International journal of Immunopathology, allergology, infectology.

The role of Corynebacterium non diphtheriae in induced apoptosis of mice macrophages

Kharseeva G.G., Voronina N.A., Alutina E.L., Mironov A.J., Mamucheva N.I., Golovanova N.A.

The task of oue investigation was study the role of programmed cell death induced by Corynebacterium non diphtheriae in alteration of white mice macrophages. The apoptogenic action of Corynebacterium non diphtheriae stamms which were taken from upper respiratory tract and urogenital tract towards to white mice macrophages was estimated. It was established that the highest apoptogenic effect had stamms taken from upper respiratory tract (96,2 2,7%) in compare with stamms taken from urogenital tract (59,4 7/0%). The ability of Corynebacterium non diphtheriae to develop of different degree cell death was shown both as in monoculture and in association with another microorganisms: S.aureus, S.pyogenes, E.coli and another types of Corynebacterium non diphtheriae. Revealed ability of Corynebacterium non diphtheriae stamms in induce the programmed cell death at mice is probably related with mechanisms of their pathogenic properties realization.

Keywords

Corynebacterium non diphtheriae, macrophages, apoptogenic effect, microbs-associants.

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Reference

Kharseeva G.G., Voronina N.A., Alutina E.L., Mironov A.J., Mamucheva N.I., Golovanova N.A. Immunopathology, allergology, infectology 2012; 1:56-59